Table 2. GDF-15 in plasma samples in relation to clinicopathological factor in patients with preoperative low-risk staging*.
| Low, n (%) | High, n (%) | P-value# | |
|---|---|---|---|
| Age, years | 0.005 | ||
| <66 | 59 (83) | 12 (17) | |
| ≥66 | 48 (62) | 19 (38) | |
| FIGO | 0.36 | ||
| I/II | 98 (74) | 35 (26) | |
| III/IV | 9 (60) | 6 (40) | |
| Histologic type | 0.218 | ||
| Endometrioid | 103 (74) | 37 (26) | |
| Non-endometrioid | 4 (50) | 4 (50) | |
| Non-endometrioid types | 0.242 | ||
| Clear cell | 0 | 1 (100) | |
| Serous | 3 (50) | 3 (50) | |
| Carcinosarcomas | 1 (100) | 0 | |
| Histologic grade** | 0.007 | ||
| Grade 1 | 70 (82) | 15 (18) | |
| Grade 2 | 24 (57) | 18 (43) | |
| Grade 3 | 5 (56) | 4 (44) | |
| Myometrial infiltration | 0.007 | ||
| <50% | 73 (80) | 18 (20) | |
| ≥50% | 34 (60) | 23 (40) |
*Low-risk patients defined as endometrioid histology and grade 1 or grade 2 disease on preoperative curettage.
**Endometrioid included only.
#P-values are calculated by Chi-square test or Fisher exact test.
Low = 1. and 2. tertile
High = 3. tertile
FIGO: International Federation of Gynecology and Obstetrics