Fig 2. CB1 receptor antagonism in the basolateral amygdala impairs memory destabilization when performed before memory reactivation.
MK-801 injection (0.1 mg/ml, i.p.) impaired memory reconsolidation in the long-term memory test (PR-LTM) in the groups infused with vehicle either before (A; simple main effect of injection, p = 0.006) or immediately after (B; p = 0.023) memory reactivation. While pre-reactivation infusion of SR141716A (8 μg/μl) seemed to prevent the amnestic effect of MK-801 (C; p = 0.25), post-reactivation infusion did not (D; p = 0.021. However, there was no significant interaction between the timing of infusion and the effect of MK-801 (Timing x Infusion x Injection: F(1,41) = 1.11, p = 0.30, η2p = 0.026). No effect of MK-801 injection or SR141716A infusion is observed in the short-memory test at 3h (PR-STM). Data are presented as individual units and mean. n = 6 per group, except for pre-reactivation SR141716 + Saline, in which n = 7.