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DOX-loaded Exos induce apoptosis more efficiently than free DOX.
Notes: PCCs were treated with vehicle, free DOX, PCC-Exo-DOX, PSC-Exo-DOX, or MØ-Exo-DOX (with free DOX equivalent 85.32 nM). Following 48 h of treatment, the percentage of apoptotic cells was determined by Annexin V-binding assay, using flow cytometry.
Abbreviations: 7-AAD, 7-amino-actinomycin; DOX, doxorubicin; Exos, exosomes; MØ, macrophage; PCCs, pancreatic cancer cells; PSCs, pancreatic stellate cells.
