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. 2019 Jan 11;14:469–481. doi: 10.2147/IJN.S191504

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© 2019 Peng et al. This work is published and licensed by Dove Medical Press Limited

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CURN reversed the immunosuppressive activity of S. aureus biofilm-treated MDSCs on T cells.

Notes: The differentiation rate of naive T cells after receiving CD3/CD28 beads stimulation was set as 100% (the mosaic bar). The changes in T-cell differentiation rate were measured after coculturing with MDSCs, which were pretreated with different concentrations of CURN and biofilm. Data are expressed as the mean ± SD. *P<0.05 and **P<0.01 compared to the biofilm-induced but no CURN treated group.

Abbreviations: CURN, curcumin nanoparticles; MDSCs, myeloid-derived suppressor cells; S. aureus, Staphylococcus aureus.