Table 1. Characterization of selected protein candidates in CIR–induced, sham and BHD treatment ischemic stroke mice.
| Protein IDs (UniProtKB) |
Gene Symnol | Description | Related pathway (PANTHER) | CIR/Sham, Log2 | (CIR+BHD)/Sham, Log2 | ||
|---|---|---|---|---|---|---|---|
| Q61838 | A2M | Alpha-2-macroglobulin;Alpha-2-macroglobulin 165 kDa subunit | 1. Blood coagulation 2. Inflammation mediated by chemokine and cytokine signaling pathway 3. Interleukin signaling pathway |
-1.35 | ** | 0.11 | ## |
| P60710 | ACTB | Actin, cytoplasmic 2; Actin, cytoplasmic 2, N-terminally processed | 1. Alzheimer disease-presenilin pathway 2. Cadherin signaling pathway 3. Cytoskeletal regulation by Rho GTPase 4. Huntington disease 5. Inflammation mediated by chemokine and cytokine signaling pathway 6. Integrin signalling pathway 7. Nicotinic acetylcholine receptor signaling pathway 8. Wnt signaling pathway |
-0.38 | ** | 1.19 | ## |
| P63260 | ACTG1 | Actin, cytoplasmic 1; Actin, cytoplasmic 1, N-terminally processed | 1. Alzheimer disease-presenilin pathway 2. Cadherin signaling pathway 3. Cytoskeletal regulation by Rho GTPase 4. Huntington disease 5. Inflammation mediated by chemokine and cytokine signaling pathway 6. Integrin signalling pathway 7. Nicotinic acetylcholine receptor signaling pathway 8. Wnt signaling pathway |
-0.38 | ** | 1.19 | ## |
| Q03157 | APLP1 | Amyloid-like protein 1 | Alzheimer disease-presenilin pathway | 0.11 | -0.70 | # | |
| P12023 | APP | Amyloid precursor protein | Alzheimer disease-presenilin pathway | -0.09 | -1.12 | # | |
| Q61361 | BCAN | Brevican core protein | Alzheimer disease-presenilin pathway | 0.39 | -0.92 | ## | |
| Q923D2 | BLVRB | Flavin reductase (NADPH) | Interleukin signaling pathway ATP synthesis |
0.35 | -0.86 | ## | |
| P07743 | BPIFA2 | BPI fold-containing family A member 2 | —— | 1.00 | ** | 1.25 | |
| P06684 | C5 | Complement C5 | 1. Inflammation mediated by chemokine and cytokine signaling pathway | -0.77 | ** | 0.41 | ## |
| P13634 | CA1 | Carbonic anhydrase 1 | —— | 0.37 | ** | -0.71 | ## |
| Q8R464 | CADM4 | Cell adhesion molecule 4 | 1. Integrin signaling pathway | 1.34 | ** | 0.02 | ## |
| Q4VAA2 | CDV3 | Protein CDV3 | —— | 0.36 | -1.36 | # | |
| P23953 | CES1C | Carboxylesterase 1C | 1. Alzheimer disease-presenilin pathway | -1.70 | ** | -0.17 | ## |
| Q9QUN9 | DKK3 | Dickkopf-related protein 3 | 1. Wnt signaling pathway 2. p53 pathway |
1.81 | * | -0.52 | ## |
| E9Q557 | DSP | Desmoplakin | 1. Apoptosis signaling pathway 2. Interleukin signaling pathway |
-0.18 | 2.09 | ## | |
| P62631 | EEF1A2 | Elongation factor 1-alpha 2 | 1. PI3 kinase pathway | -0.34 | 1.95 | ## | |
| Q99M71 | EPDR1 | Mammalian ependymin-related protein 1 | 1. Gonadotropin releasing hormone receptor pathway 2. Integrin signaling pathway |
0.65 | ** | -0.20 | ## |
| Q8R0W0 | EPPK1 | Epiplakin | 1. Cytoskeletal regulation by Rho GTPase | -0.05 | 2.61 | ## | |
| P49945 | FTL2 | Ferritin light chain 2 | 1. Integrin signaling pathway | 1.29 | ** | 0.35 | ## |
| Q02596 | GLYCAM1 | Glycosylation-dependent cell adhesion molecule 1 | 1. Inflammation mediated by chemokine and cytokine signaling pathway | 0.51 | ** | -0.31 | ## |
| P24472 | GSTA4 | Glutathione S-transferase A4 | —— | 0.64 | -1.19 | ## | |
| P62806 | HIST1H4A | Histone H4 | ——- | -0.41 | 2.32 | ## | |
| Q61696 | HSPA1A | Heat shock 70 kDa protein 1A | 1. Apoptosis signaling pathway 2. Gonadotropin releasing hormone receptor pathway 3. Parkinson disease |
-0.77 | ** | 1.75 | ## |
| P17879 | HSPA1B | Heat shock 70 kDa protein 1B | 1. Apoptosis signaling pathway 2. Gonadotropin releasing hormone receptor pathway 3. Parkinson disease |
-0.77 | ** | 1.75 | ## |
| Q02257 | JUP | Junction plakoglobin | 1. Alzheimer disease-presenilin pathway | -0.54 | 2.14 | ## | |
| P28665 | MUG1 | Murinoglobulin-1 | ——- | -1.12 | ** | 0.05 | ## |
| P02762 | MUP6 | Major urinary protein 6 | ——- | 1.67 | * | 0.77 | |
| P04938 | MUP8 | Major urinary proteins 8 | ——- | 1.67 | * | 0.77 | |
| Q5SX40 | MYH1 | Myosin-1 | 1. Cytoskeletal regulation by Rho GTPase 2. Inflammation mediated by chemokine and cytokine signaling pathway 3. Nicotinic acetylcholine receptor signaling pathway 4. Wnt signaling pathway |
1.49 | ** | 1.27 | ## |
| Q5SX39 | MYH4 | Myosin-4 | 1. Cytoskeletal regulation by Rho GTPase 2. Inflammation mediated by chemokine and cytokine signaling pathway 3. Nicotinic acetylcholine receptor signaling pathway 4. Wnt signaling pathway |
1.63 | 2.61 | ||
| P13542 | MYH8 | Myosin-8 | 1. Cytoskeletal regulation by Rho GTPase 2. Inflammation mediated by chemokine and cytokine signaling pathway 3. Nicotinic acetylcholine receptor signaling pathway 4. Wnt signaling pathway |
1.44 | ** | 1.41 | |
| Q8VDD5 | MYH9 | Myosin-9 | 1. Cytoskeletal regulation by Rho GTPase 2. Inflammation mediated by chemokine and cytokine signaling pathway 3. Nicotinic acetylcholine receptor signaling pathway |
1.09 | * | 3.44 | ## |
| P05977 | MYL1 | Myosin light chain 1/3, skeletal muscle isoform | 1. Integrin signaling pathway | 2.79 | ** | 1.37 | # |
| Q99J85 | NPTXR | Neuronal pentraxin receptor | 1. Alzheimer disease-presenilin pathway | -0.37 | 0.18 | ## | |
| P63054 | PCP4 | Purkinje cell protein 4 | 1. Gonadotropin releasing hormone receptor pathway | 4.32 | ** | 2.26 | # |
| Q7TMJ8 | PIK3IP1 | Phosphoinositide-3-kinase-interacting protein 1 | 1. PI3 kinase pathway 2. p53 pathway |
0.42 | -0.50 | ## | |
| P97350 | PKP1 | Plakophilin-1 | 1. Cytoskeletal regulation by Rho GTPase 2. Apoptosis signaling pathway |
-0.47 | 3.20 | ## | |
| Q9QXS1 | PLEC | Plectin | 1. Cytoskeletal regulation by Rho GTPase 2. Integrin signaling pathway |
0.52 | 2.72 | ## | |
| Q8K4L4 | POF1B | Protein POF1B | 1. Ubiquitin proteasome pathway | -0.67 | 2.27 | ## | |
| Q9ERT9 | PPP1R1A | Protein phosphatase 1 regulatory subunit 1A | —— | -0.30 | -1.15 | ## | |
| Q61171 | PRDX2 | Peroxiredoxin-2 | 1. p53 pathway 2. Apoptosis signaling pathway |
1.01 | * | -0.53 | ## |
| O09114 | PTGDS | Prostaglandin-H2 D-isomerase | 1. Alzheimer disease-presenilin pathway | -0.01 | -0.58 | ## | |
| Q9WUB3 | PYGM | Glycogen phosphorylase, muscle form | 1. Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | 1.62 | 2.27 | ## | |
| P62983 | RPS27A | Ubiquitin-40S ribosomal protein S27a | 1. Interleukin signaling pathway | 1.35 | ** | -0.04 | ## |
| P50114 | S100B | Protein S100-B | 1. Inflammation mediated by chemokine and cytokine signaling pathway | 0.01 | -1.45 | ## | |
| P47867 | SCG3 | Secretogranin-3 | 1. Alzheimer disease-presenilin pathway 2. Huntington disease |
0.33 | -0.49 | ## | |
| P70124 | SERPINB5 | Serpin B5 | 1. p53 pathway | -1.07 | * | 3.44 | ## |
| Q4V9Z5 | SEZ6L2 | Seizure 6-like protein 2 | 1. Alzheimer disease-presenilin pathway | 0.51 | * | -0.44 | ## |
| P54227 | STMN1 | Stathmin 1 | 1. Cytoskeletal regulation by Rho GTPase 2. PI3 kinase pathway |
1.69 | ** | -0.98 | ## |
| P61957 | SUMO2 | Small ubiquitin-related modifier 2 | 1. p53 pathway | 0.73 | -1.50 | ## | |
| Q9JLF6 | TGM1 | Protein-glutamine gamma-glutamyltransferase K | ——- | -0.59 | 1.19 | ## | |
| P68369 | TUBA1A | Tubulin alpha-1A chain | 1. Gonadotropin releasing hormone receptor pathway 2. Cytoskeletal regulation by Rho GTPase |
2.53 | ** | 0.68 | ## |
| P05213 | TUBA1B | Tubulin alpha-1B chain | 1. Gonadotropin releasing hormone receptor pathway 2. Cytoskeletal regulation by Rho GTPase |
2.53 | ** | 0.68 | ## |
| P68373 | TUBA1C | Tubulin alpha-1C chain | 1. Gonadotropin releasing hormone receptor pathway 2. Cytoskeletal regulation by Rho GTPase |
2.53 | ** | 0.68 | ## |
| P05214 | TUBA3A | Tubulin alpha-3 chain | 1. Gonadotropin releasing hormone receptor pathway 2. Cytoskeletal regulation by Rho GTPase |
2.53 | ** | 0.68 | ## |
| Q9D6F9 | TUBB4A | Tubulin beta-4A chain | 1. Cytoskeletal regulation by Rho GTPase 2. Huntington disease |
1.01 | 3.54 | ## | |
| P68372 | TUBB4B | Tubulin beta-4B chain | 1. Cytoskeletal regulation by Rho GTPase 2. Huntington disease |
1.19 | 3.48 | ## | |
| P0CG49 | UBB | Polyubiquitin-B | 1. Huntington disease 2. Wnt signaling pathway 3. Ubiquitin proteasome pathway |
1.35 | ** | -0.04 | ## |
| P0CG50 | UBC | Polyubiquitin-C | 1. Huntington disease 2. Wnt signaling pathway 3. Ubiquitin proteasome pathway |
1.35 | ** | -0.04 | ## |
*P < 0.05
**P < 0.01 compared to the control group.
#P < 0.05
##P < 0.01 compared to the CI/R group