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. Author manuscript; available in PMC: 2019 Nov 1.
Published in final edited form as: Cell. 2018 Nov 1;175(4):921–933.e14. doi: 10.1016/j.cell.2018.10.033

Figure 7. Model for CdiA surface topology and receptor-triggered toxin delivery.

Figure 7.

A) Model of CdiA surface topology. Receptor recognition (1) triggers export of the C-terminal half of CdiA (2). The FHA-2 domain interacts with the target-cell outer membrane (3), perhaps forming a β-barrel translocon. Once transferred into the target-cell periplasm, the CdiA-CT region is cleaved (4) for transport into the cytoplasm (5). B) RBD size is proportional to filament length. RBD residues are plotted as a function of FHA-1 residues. See Figure S3 & Table S2. C) Plot of FHA-2 versus FHA-1 residues for the effectors in panel B. See Table S2.