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Schematic model of LINC00673-mediated senescence bypass in lung ADC. Constitutive mitogenic signaling e.g. by oncogenic Ras triggers p53 accumulation and activation resulting in cell cycle arrest and cellular senescence. In lung cells overexpressing oncogenic LINC00673, TP53 translation is reduced by direct interactions between the TP53 3ʹUTR and LINC00673. Consequently, p53-mediated cell cycle arrest is abrogated leading to bypass of cellular senescence.
