Figure 1. SNP associations with lifespan across both parents under the assumption of common and sex-specific effect sizes.
Miami plot of genetic associations with joint parental survival. In purple are the associations under the assumption of common SNP effect sizes across sexes (CES); in green are the associations under the assumption of sex-specific effect sizes (SSE). P refers to the two-sided P values for association of allelic dosage on survival under the residualised Cox model. The red line represents our multiple testing-adjusted genome-wide significance threshold (p = 2.5 × 10−8). Annotated are the gene, set of genes, or cytogenetic band near the index SNP, marked in red. P values have been capped at –log10(p) = 15 to better visualise associations close to genome-wide significance. SNPs with P values beyond this cap (near APOE, CHRNA3/5 and LPA) are represented by triangles.