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. Author manuscript; available in PMC: 2019 Jan 15.
Published in final edited form as: Adv Exp Med Biol. 2018;1044:15–25. doi: 10.1007/978-981-13-0593-1_2

Figure 2 : Translocation mechanisms in human with programmable nucleases.

Figure 2 :

Chromosomal translocations in human cells are principally formed by c-NHEJ (a) although a small contribution of alt-NHEJ cannot be excluded (b). In absence of active c-NHEJ, the contribution of alt-NHEJ become critical (c).