Table 1.

Comparison of TNFR1 and TNFR2

TNFR1	TNFR2
Expressed ubiquitously on most cells Preferentially activated by soluble TNF Dominant receptor involved in inflammatory and innate immune responses Excessive signaling is the culprit in inflammatory disease states Shows comparable binding affinity to TNF and PGRN	Expression limited to certain cell types (e.g., immune cells, neurons, endothelium) Preferentially activated by transmembrane TNF Mediates anti-inflammatory and homeostatic functions of TNF Signaling may be protective in inflammatory disease states; shown to have immunomodulatory functions Has approximately 600-fold higher binding affinity to PGRN than TNF