Fig. 2.

Circadian rhythm parameters in cells from Li-R and Li-NR donors. a There was no difference in amplitude in cells donated by Li-R (N = 44) and Li-NR (N = 15), either at baseline (untreated) or after cells were treated with lithium 1 mM. b Period length was more likely to be short in cells from Li-R donors compared to cells from Li-NR. Mean period Li-R 25.5 ± 0.14 vs. Li-NR 26.0 ± 0.17 h, two-tailed T test indicates p = 0.08. c The proportion of Li-R and Li-NR differs significantly in donors with short and long circadian period [Χ² = 4.06(1), OR = 3.6, * indicates p < 0.05]. Short/Long corresponds to below/above the median period of 25.8 h. d Representative rhythm traces of cells from Li-R (blue) and Li-NR (red) subjects. Error bars represent SEM