Figure 7.

Implementation of multidimensional in vitro screenings for biological data-integrative read-across applications. GHS-like transformation criteria (Supplemental Table 1) for 21 in vivo phenotypes (Supplemental Table 9) from five major toxicity categories provided the basis for comprehensive in vivo toxicity profiling and ranking of 20 glycol ethers (A). In vivo data were accessible through official REACH submissions of The Dow Chemical Company. Correlation analysis between in vitro and in vivo, as well as in vitro and in vivo irritation ToxPi scores for E- and P-Series glycol ethers are shown in panels A and B. Pearson’s r and Spearman’s ρ correlation coefficients including significance levels are indicated.