Table 3:

General grading guidelines from the Common Terminology Criteria for Adverse Events^*12

CTCAE grade	Description
1	Mild; asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated.
2	Moderate; minimal, local or noninvasive intervention indicated; limiting age appropriate instrumental activity of daily living.
3	Severe or medically significant but not immediately life-threatening; hospitalization indicated; disabling; limiting self care.
4	Life-threatening consequences; urgent intervention indicated.
5	Death related to adverse event.

Note: CTCAE = Common Terminology Criteria for Adverse Events.

^*CTCAE provides general grading guidelines as described within this table. For each specific organ affected, the CTCAE also provides descriptive organ-specific grading.¹²