Table 3.
Spontaneous vs probed symptom expressions during the CE portion of the interviews
| Symptom Reported, n (%) | Participants, N = 20 | |||
|---|---|---|---|---|
| Spontaneous | Probed | Not Affected | Not Reported | |
| Itching-related signs and symptoms | ||||
| Itching on the legs | 15 (75) | – | – | 5 (25) |
| Itching on the arms | 11 (55) | 2 (10) | – | 7 (35) |
| Itching on the back | 9 (45) | 1 (5) | – | 10 (50) |
| Itching on the sides | 9 (45) | 1 (5) | – | 10 (50) |
| Itching on the abdomen | 7 (35) | 2 (10) | – | 11 (55) |
| Itching on the head | 6 (30) | – | – | 14 (70) |
| Itching on the feet | 3 (15) | – | – | 17 (85) |
| Itching on the hands | 3 (15) | – | – | 17 (85) |
| Itching on the face | 2 (10) | 1 (5) | – | 17 (85) |
| Itching on the chest | 1 (5) | – | – | 19 (95) |
| Itching on the groin | 1 (5) | – | – | 19 (95) |
| Hives | 1 (5) | – | – | 19 (95) |
| Rash | 1 (5) | – | – | 19 (95) |
| Energy-related signs and symptoms | ||||
| Fatigue | 15 (75) | 1 (5) | 2 (10) | 2 (10) |
| Tiredness | 6 (30) | – | – | 14 (70) |
| Lack of energy | 3 (15) | – | – | 17 (85) |
| Exhausted | 2 (10) | – | – | 18 (90) |
| Weakness | 2 (10) | 10 (50) | 8 (40) | – |
| Gastrointestinal signs and symptoms | ||||
| Nausea | 6 (30) | – | – | 14 (70) |
| Diarrhea | 4 (20) | 8 (40) | 8 (40) | – |
| Othera | 3 (15) | 1 (5) | – | 16 (80) |
| Abdominal bloating | 2 (10) | 10 (50) | 6 (30) | 2 (10) |
| Changes in appetite | – | 5 (25) | 14 (70) | 1 (5) |
| Greasy diarrhea | 1 (5) | 7 (35) | 11 (55) | 1 (5) |
| Urgency with bowel movements | – | 12 (60) | 7 (35) | 1 (5) |
| Cognitive signs and symptoms | ||||
| Difficulty concentrating | 3 (15) | 11 (55) | 6 (30) | – |
| Difficulty remembering things | 2 (10) | 12 (60) | 6 (30) | – |
| Pain and discomfort | ||||
| Bone pain/aches | 5 (25) | 2 (10) | – | 13 (65) |
| Muscle pain/aches | 4 (20) | – | – | 16 (80) |
| Abdominal pain | 3 (15) | 9 (45) | 7 (35) | 1 (5) |
| Discomfort in right side | 3 (15) | 11 (55) | 5 (25) | 1 (5) |
| General pain | – | 4 (20) | 4 (20) | 12 (60) |
| Joint pain/aches | 3 (15) | 2 (10) | – | 15 (75) |
| Otherb | 1 (5) | 1 (5) | – | 18 (90) |
| Additional signs and symptoms | ||||
| Dry eyes | 6 (30) | 8 (40) | 6 (30) | – |
| Difficulty staying asleep | 5 (25) | 11 (55) | 4 (20) | – |
| Dry mouth | 4 (20) | 9 (45) | 7 (35) | – |
| Hair loss | 4 (20) | – | – | 16 (80) |
| Otherc | 4 (20) | – | – | 16 (80) |
| Difficulty falling asleep | 2 (10) | 8 (40) | 9 (45) | 1 (5) |
| Weak/brittle bones | 2 (10) | 1 (5) | 17 (85) | – |
| Darkening of the skin | 1 (5) | 7 (35) | 12 (60) | – |
| Fatty deposits on skin | 1 (5) | 5 (25) | 14 (70) | – |
| Gall stones | – | 3 (15) | 3 (15) | 14 (70) |
| Jaundice | 1 (5) | 1 (5) | 18 (90) | – |
| Kidney stones | – | 5 (25) | 9 (45) | 6 (30) |
| Swelling | – | 10 (50) | 10 (50) | – |
CE, concept elicitation
aAcid reflux, constipation, fewer stools, don’t process vitamins/minerals properly
bHeadache, migraine
cWeight gain, weight loss, restless legs, sweating, skin flushed, heavy menstruation