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. 2019 Jan 9;9:3292. doi: 10.3389/fmicb.2018.03292

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Copyright © 2019 Qiao, Han, Feng, Zheng, Wu, Gao, Yang, You, Liu and Wu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Observation of type 2 diabetes mellitus symptoms. (A) A total of 10, 13-week-old GK rats were used in this work and randomly divided into two groups. The rats in the BD3526 group were gavaged daily with 2 mLlyophilized powder of the BD3526 strain fermentation products (50 mg/mL), whereas the GK rats in the control group were gavaged daily with 2 mL physiological saline. All of the animals were permitted free access to normal chewing bars and water. At intervals of 0, 2, 3, and 6 weeks, the changes of diabetes indexes in these rats were observed. At the sixth week, the gavage of either BD3526 strain fermentation products or physiological saline was interrupted and the rats were restored to normal diets. After the restoration, the animals were anesthetized and killed, and the mucus in the intestine and colon was scratched. It is desirable to observe changes in the phenotype after stopping the ingestion of the BD3526 strain fermentation products. (B) Postprandial blood glucose measurements were performed in the BD3526 group and the control group. The x-axis represents the time of the week. The y-axis represents the postprandial blood glucose concentration (mM/L). The asterisk represents a significant difference in blood glucose concentration between the BD3526 group and the control group (^∗P-value < 0.05, mean ± SEM). (C) The glycated hemoglobin (HbA1c) test confirmed that the blood glucose concentration in the BD3526 group was significantly lower than that in the control group (^∗∗P-value < 0.01, mean ± SEM). (D) Body weight indicators were used to assess weekly body weight changes in the BD3526 group and control group models (mean ± SEM).