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. 2019 Jan 9;9:3054. doi: 10.3389/fimmu.2018.03054

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Copyright © 2019 Wangkahart, Secombes and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The modulation of the expression of SOCS genes in vivo by YRF. Rainbow trout were ip injected with YRF or PBS, sampled and analyzed as described in Figure 2. The expression of CISHa1 (A), CISHa2 (B), SOCS1 (C), SOCS3A (D), SOCS3B2 (E), SOCS6A1 (F) SOCS6A2 (G) SOCS6B2 (H) SOCS7B2 (I) was examined. A fold change was calculated as the average expression level of YRF injected fish divided by that of time matched controls. The means + SEM of six fish are shown. Significant differences between injected fish and controls were tested by one way-ANOVA followed by the Bonferroni post hoc test, and are shown over the bars as; ^*p < 0.05, ^**p < 0.01, and ^***p < 0.001.