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. 2018 Sep 22;46(2):288–296. doi: 10.1007/s00259-018-4149-2

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© The Author(s) 2018

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 1 — Axial view of [18F]Florbetaben PET amyloid load in mild cognitive impairment. Average axial slices of mild cognitive impairment subjects with low (Aß-; top panel) and high amyloid load (Aß+; bottom panel). Subjects were classified using k-means clustering. Signal intensity is significantly lower in the grey matter regions of the top images compared to those of the bottom images (P < 0.0001)