Table 2.
Sensitivity and specificity of amyloid accumulation on cognitive decline
| Cognitive status | Aß+ | Aß− | Chi square | P | Sensitivity (95%CI) | Specificity (95%CI) | OR (95%CI) | PPV (95%CI) | NPV (95%CI) |
|---|---|---|---|---|---|---|---|---|---|
| EMCs+ | 28 (80%) | 7 (20%) | |||||||
| EMCs- | 6 (21%) | 22 (79%) | 21.48 | <0.00001 | 80% (67–93) | 79% (63–94) | 14.67 (4.3–49.9) | 82% (70–95) | 76% (60–91) |
| NMCs+ | 23 (72%) | 9 (28%) | |||||||
| NMCs- | 11 (35%) | 20 (65%) | 8.39 | 0.0038 | 72% (56–87) | 65% (48–81) | 4.65 (1.6–13.5) | 68% (52–83) | 69% (52–86) |
| aMCI+ | 18 (72%) | 7 (28%) | |||||||
| aMCI- | 16 (42%) | 22 (58%) | 5.42 | 0.0199 | 72% (54–90) | 58% (42–74) | 3.54 (1.2–10.5) | 53% (36–70) | 76% (60–91) |
Aß+= MCI subjects with Aß burden below the threshold of SUVR>1.3; Aß−= MCI subjects with Aß burden below the threshold of SUVR<=1.3; EMCs+ = MCI subjects with episodic memory composite score < = 0.125; EMCs- = MCI subjects with episodic memory composite score > 0.125; NMCs+ = MCI subjects with Non-memory composite score < = 0.06; NMCs- = MCI subjects with Non- memory composite score > 0.06; aMCI+ = MCI subjects with MMSE score < = 24; aMCI- = MCI subjects with MMSE score > 24; CI = confidence interval; OR = Odd ratio; PPV = positive predictive value; NPV = negative predictive value;