Table 1.
Overview the role of autophagy mechanism in vitro and in vivo models about hearing.
| Model | Disease model | Drug / Target | Dose | Sample Size | Hearing threshold shift | Histological observations | Autophagy mechanism | Reference |
|---|---|---|---|---|---|---|---|---|
| C57BL/6 mice (8W) | Atg5-/- in HCs | / | / | 14 | 80–90 dB↑ (8,16 kHZ) | HCs damaged | Autophagosome formation impaired | Fujimoto et al., 2017 |
| CBA/J mice (12W) | NIHL (TTS) | 3-MA | 30 mg/kg | 6 | 25 dB ↑ (16 kHZ) | OHCs loss severely | Autophagy level decreased | Yuan et al., 2015 |
| CBA/J mice (12W) | NIHL (PTS) | Rapamycin | 7.5 mg/kg | 14 | 15 dB↓ (16 kHZ) | Remained OHCs increased | Autophagy level upregulated | Yuan et al., 2015 |
| HEI-OC1 cells | Neomycin | 3-MA | 5 mM for 6 h | / | / | TUNEL positive cells increased | Autophagy level decreased | He et al., 2017 |
| HEI-OC1 cells | Neomycin | Rapamycin | 0.1 mM for 6 h | / | / | TUNEL positive cells decreased | Autophagy level upregulated | He et al., 2017 |
| Wistar rats (8w) | Cisplatin | Rapamycin | 2 mg/Kg | 8 | 20dB↓ (16kHZ) | Alleviated HC damage | Autophagy level upregulated | Fang and Xiao, 2014 |
| HEI-OC1 cells | ARHL | Si-ATG9a | 20 μM | / | / | Survival cells decreased | Autophagic flux inhibited | Pang et al., 2017 |