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. 2019 Jan 9;9:3014. doi: 10.3389/fimmu.2018.03014

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Copyright © 2019 Chowdhury, Narra, Sahni, Khanipov, Fofanov and Sahni.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Heterologous reporter assays demonstrating enhancer activity of elncRNA loci. Co-transfection of enhancer reporter construct (sense or antisense orientation) and Renilla reporter plasmid in NIH3T3 cells and Raw 264.7 murine macrophages. (A,B) Transfection of NONMMUT013718 and NONMMUT024103 elncRNA constructs (sense orientation) in NIH3T3 cells, and (C,D) in Raw 264.7 murine macrophages, respectively; (E,F) Transfection of NONMMUT013718 and NONMMUT024103 elncRNA constructs (anti-sense orientation) in NIH3T3 cells, and (G,H) in Raw 264.7 murine macrophages, respectively. The data are presented as Mean ± SEM for six independent (n = 6) experiments. The negative controls are blank promoter plasmid or inserts with minimal H3K4Me1/H3K4Me3 ratio (Neg E1 and E2). The levels of significance are shown as **P ≤ 0.01; ***P ≤ 0.001.