Fig. 1.

Effects of BDNF genotype and schizophrenia familial risk on ACC–mPFC functional connectivity. Effects of BDNF Val⁶⁶Met genotype on ACC–PFC functional connectivity in discovery (a) (t = 5.02; p_FWE = 0.022, whole-brain corrected) and replication sample (b) (t = 3.72; p_FWE = 0.022, region of interest corrected). c ACC–PFC functional connectivity in a sample of healthy first-degree relatives compared with healthy controls without a history of mental illness (t = 3.39; p_FWE = 0.05, region of interest corrected). Depictions at p = 0.005 uncorrected