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. 2019 Jan 15;9:121. doi: 10.1038/s41598-018-37138-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Conolidine and cannabidiol inhibition of currents through transiently expressed human Ca_v2.2 channels. (a) Time course of I_Ba in the absence (control) and presence of 30 μM conolidine. Bar indicates conolidine application. I_Ba was evoked by 40-ms depolarizations to +15 mV, applied every 15 s from a holding potential of −80 mV (voltage inset). Representative inset I_Ba traces in the absence and presence of conolidine are shown at the times indicated by lowercase letters and the red filled circle, respectively. Horizontal dotted line represents zero-current level. (b) Mean current-voltage (I-V) relationships in the absence (control) and presence of conolidine (30 μM). (c) Summary of I_Ba inhibition by conolidine. The whisker box plot displays the median and the lower and upper quartiles; whiskers represent the minimum and maximum of the data (n = 7). (d) Time course of peak I_Ba in the absence and presence of 1 μM and 10 μM cannabidiol (lowercase letters and red filled circles, respectively). Data presentation and voltage protocol similar to that shown in a. (e) Mean I-V relationships in the absence (control) and presence of cannabidiol. (f) Summary of I_Ba inhibition by 1 μM and 10 μM cannabidiol (n = 7 and 8, respectively).