Fig. 1.

Effects of WAY163909 on reversal learning measures before METH or HCD exposure. Subjects participated in a DRL task in which several measures were taken during reversal sessions. Dose-effect curves for WAY163909 (0.1, 0.3, and 1.0 mg/kg) were established for the following measures: a correct responses, b perseverative errors, c random errors, and d acquisition latency (days). The data are presented as the group mean ± SEM, where N = 10 for each experimental condition, except for the 1.0 mg/kg WAY163909 dose condition, for which N = 9. **p < 0.01 for correct responses compared to vehicle; ****p < 0.0001 for correct responses and perseverative errors compared to vehicle