Fig. 3.

Effects of combined pretreatment with WAY163909 and SB242084 on reversal learning measures after METH exposure. Subjects in the METH group (N = 5) self-administered METH for 6 months. Afterward, post-METH exposure perseverative behavior was measured using a DRL task under the following experimental conditions: vehicle, 1.0 mg/kg WAY163909, and 1.0 mg/kg WAY163909 + 0.1 mg/kg SB242084. Effects of these pretreatments are shown for a correct responses and b perseverative errors. The effects of WAY163909 and SB242084 before and after METH exposure are shown for c correct responses (% of vehicle) and d perseverative errors (% of vehicle). The data are presented as the group mean ± SEM for each experimental condition. ***p < 0.001 for post-METH exposure correct responses compared with vehicle; ****p < 0.0001 for post-METH exposure perseverative errors compared with vehicle; bars with the same letter (a or b) are not statistically different, while bars with different letters denote statistical difference