Fig. 4.

Effects of combined pretreatment with WAY163909 and SB242084 on reversal learning measures after HCD exposure. Subjects in the HCD group (N = 5) were given access to both a LCD and a palatable HCD for 6 months. Post-HCD exposure perseverative behavior was measured under the following conditions: vehicle, high WAY163909, and high WAY163909 + 0.1 mg/kg SB242084. Effects of these pretreatments are shown for a correct responses and b perseverative errors. The effects of WAY163909 and SB242084 before and after HCD exposure are shown for c correct responses (% of vehicle) and d perseverative errors (% of vehicle). The data are presented as the group mean ± SEM for each experimental condition. **p < 0.01 for post-HCD exposure perseverative errors compared with vehicle; ****p < 0.0001 for post-HCD exposure correct responses compared with vehicle; bars with the same letter (a or b) are not statistically different, while bars with different letters denote statistical difference