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. 2019 Jan 15;9:131. doi: 10.1038/s41598-018-37464-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Dietary bile acid supplementation in two mouse strains, C57BL/6J (panels A–C) and 129S6/SvEvTac (panels D–F), fed control or high fat diet (C and H, white fill) and the respective versions supplemented with cholate (CC and HC, grey fill). (A) Body mass change trajectories along four weeks of feeding trial. Cholate supplementation decreased body mass accumulation in both diet groups with a stronger effect in high fat diet (LME). (B) Lean mass after completion of the feeding trial. (C) Fat mass after completion of the feeding trial. (D) Body mass change trajectories along four weeks of feeding trial. Cholate supplementation had no effect in any group of 129S6/SvEvTac mice (LME). (E) Lean mass after completion of the feeding trial. (F) Fat mass after completion of the feeding trial. All data are mean values ± SD; n = 6–7 (A–C) and 5–6 (D,F); results of 2-way-ANOVA in italics (B,C,E,F) with ^#significant effect; *significantly different (t-test post-hoc); LME = tested by linear mixed effects model fit, see materials and methods.