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. 2019 Jan 15;9:131. doi: 10.1038/s41598-018-37464-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Bile acid intake and organismic distribution in mice of two strains, C57BL/6J and 129S6/SvEvTac fed control or high fat diet (C and H, white fill) or the respective versions supplemented with cholate (CC and HC, grey fill). (A) Mean daily cholate intake from supplemented diets during the 4 week feeding trial, mean ± SD, n.s. = not significantly different (t-test). (B) Fecal bile acid excretion is increased by cholate supplementaion in both diets (p < 0.0001). (C) Bile acid amount sequestered within enterohepatic organs is increased by cholate supplementaion in both diets (p < 0.0001, but much less so in 129S6/SvEvTac mice (p < 0.0001). (D) Plasma bile acid concentration is increased by cholate supplementaion to high fat diet (p < 0.05), but much less so in 129S6/SvEvTac mice (p < 0.05). Trends are similar in the control diet groups. Group comparisons in panels B–D were conducted by separate 2-way ANOVAs for C and H diets, n = 4–7.