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. 2019 Jan 15;9:139. doi: 10.1038/s41598-018-37437-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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EGFR inhibition resulted in elimination of EGFR-amplified populations. FISH images of the patient tumours, with EGFR probe in green and centromere 7 (CEN7) control probe in red. From left to right, panel represents the original tumour MGG70 (70), the first recurrent tumour before dacomitinib treatment MGG70R (70R), the re-recurrent tumour after dacomitinib treatment MGG70RR (70RR) and the autopsy material MGG70A (70A). Clumped amplification of EGFR is noted in 70 and 70 R, but not in 70RR and 70 A.