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. 2018 Dec 10;294(2):726–736. doi: 10.1074/jbc.REV118.005205

Figure 2.

Figure 2.

FZD5 and FZD7 subclass CRDs share a conserved α-helical dimer interface and U-shaped lipid-binding cavity. A, phylogenetic tree of hFZD CRDs. Surface representations of hFZD5 CRD in complex with C16:1n-7 fatty acid (PDB code 5URY) (B), hFZD5 CRD in complex with BOG (PDB code 5URZ) (C), apo hFZD7 CRD (PDB code 5T44) (D), or in complex with C24 fatty acid (PDB code 5URV) (E), and apo mFZD8 CRD (PDB code 1IJY) (F) are shown. Each hFZD5 CRD ligand represents 50% occupancy due to their location along the 2-fold symmetry axis and only one molecule is displayed for clarity. Surfaces within ∼7 Å of the ligand are transparent. The N terminus of hFZD7 CRD in complex with C24 fatty acid is truncated for visual clarity. Artwork by Luciana Giono.