Figure 3.

Structural basis for fatty acid recognition by Frizzled CRDs. Surface representations of the hydrophobic cavity of hFZD5 CRD in complex with C16:1n-7 (A) with a zoomed-in view without polypeptide backbone highlighting residues proximal to the hydrophobic cavity (B) are shown. C, ligand interaction map illustrating interactions between hFZD5 CRD and C16:1n-7 (PDB code 5URY). Surface representations of the hydrophobic cavity in the C24-bound hFZD7 CRD structure (D) with a zoomed-in view (PDB code 5URV) (E) are shown. F, ligand interaction map between hFZD7 and C24 fatty acid. Fatty acid carbons are numbered sequentially, starting from the carboxylic acid headgroup (C1). Artwork by Luciana Giono.