Table 1.

TAG synthases in M.tuberculosis H37Rv.

Sl No	Confirmed /putative TAG synthase in Mtb H37Rv	Essentiality for growtha,b,c	Presence of orthologs in mycobacterial sp.	Up-regulation during stress and/or growth arrest	Subcellular localizationi
1	Rv0221	Noa,b,c	Pathogenic and non-pathogenic	No	Cell membrane fraction
2	Rv0895	Noa,c Yesb	Pathogenic	No	Cellwall fraction
3	Rv1425	Noa,b,c	Pathogenic	No	Cell membrane fraction
4	Rv1760	Noa,b,c	Pathogenic	No	Not known
5	Rv2285	Noa,b,c	Pathogenic	No	cell membrane fraction
6	Rv2484c	Noa,b,c	Pathogenic and non-pathogenic	No	Cell membrane fraction
7	Rv3087	Noa,b Yesc	Pathogenic and non-pathogenic	No	Cell membrane fraction
8	Rv3088 (Tgs4)	Noa,b,c	Pathogenic	Low pH invitrod	Not known
9	Rv3130c (Tgs1)	Noa,b,c	Pathogenic and non-pathogenic	In vitro hypoxiae, nitrosative stresse, infected adipocyte modelf, sputum bacillig	Cellwall & cell membrane fractions
10	Rv3233c	Noa,b,c	Pathogenic	No	Not known
11	Rv3234c (Tgs3)	Noa,b,c	Pathogenic	In vitro hypoxiae, infected adipocyte modelf	Not known
12	Rv3371	Noa,b Yesc	Pathogenic	In vitro hypoxiae, nitrosative stresse, infected adipocyte modelf	Cell membrane fraction
13	Rv3480c	Noa,c Yesb	Pathogenic	No	Not known
14	Rv3734c (Tgs2)	Noa,b,c	Pathogenic and non-pathogenic	In vitro hypoxiae, nitrosative stresse, infected adipocyte modelf, nutrient starvationh	Cell membrane fraction
15	Rv3740c	Noa,b,c	Pathogenic	No
16	Rv3804c (FbpA)	Not clear	Pathogenic and non-pathogenic	Infected adipocyte modelf	Secreted

^aEssential for in vitro growth (Sassetti et al., 2003; Griffin et al., 2011; DeJesus et al., 2017.

^bEssential for survival in primary murine macrophages (Rengarajan et al., 2005).

^cEssential for survival in mouse spleens (Sassetti and Rubin, 2003).

^d(Singh et al., 2005);

^e(Daniel et al., 2004);

^f(Rastogi et al., 2016).

^g(Garton et al., 2008);

^h(Betts et al., 2002);

ⁱ(Mawuenyega et al., 2005).