FIGURE 3.
Selected hits show dosage-dependent pyoverdine fluorescence quenching. (A,B) Fluorescence of bacteria-free, pyoverdine-rich filtrate after 5 min incubation with the compounds indicated at either fixed (250 μM, A) or varying (B) concentrations. DMSO. (C) Structural comparison of a parent compound (LK31) and an analog with improved efficiency (LK31a). At least three biological replicates were performed for A,B. p-values were calculated using Student’s t-test, ∗p < 0.01.