Fig. 5.

Antidepressant effect of prior stimulation of mPFC Drd1 terminals in the BLA. a Experimental strategy (infusions and cannulations were bilateral) and representative cannula placements over mPFC Drd1-Cre or WT BLA terminals (green—EYFP, magenta—DAPI); scale bar 100 µM. b Photostimulation of mPFC Drd1 cell terminal field in the BLA increases cFos expression (normalized cells per mm², Mann–Whitney, p < 0.01, Drd1-Cre (n = 5) vs. Drd1-WT (n = 4), green—EYFP, red—cFos, blue—NeuN). c FST immobility time 24 h after photostimulation of mPFC Drd1 terminals in the BLA (Mann–Whitney p < 0.05) Drd1-WT, 11 males, 5 females; Drd1-Cre, 7 males, 7 females. d NSF time 24 h after photostimulation of mPFC Drd1 terminals in the BLA (Mantel–Cox (log rank) p < 0.01). Drd1-WT, 11 males, 5 females; Drd1-Cre, 6 males, 6 females; *p < 0.05, **p < 0.01. Error bars represent mean ± SEM. Male—closed data points, female—open data points