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. 2018 Apr 25;51(1):252–266. doi: 10.4143/crt.2017.613

Fig. 1.

Fig. 1.

Tumor-associated macrophages (TAMs) facilitate colorectal cancer cells metastasis. (A) Quantification of macrophages in tumor tissues of non-metastatic colorectal cancer patients (patients/N) (n=10) and metastatic colorectal cancer patients (patients/M) (n=10). (B) Immunohistochemistry and intensity analysis (n=10) for CD68 to detect the macrophages in tumor tissues of non-metastatic colorectal cancer patients (patients/N) and metastatic colorectal cancer patients (patients/M). Scale bar=100 μm. (C) The lung weight of tumor-bearing mice treated with phosphate buffered saline (PBS) or TAMs (n=10). (D) The lung node number of tumor-bearing mice treated with PBS or TAMs (n=10). (E) H&E staining of a representative lung of tumor-bearing mice treated with PBS or TAMs. Scale bar=200 μm. (F) The lung weight of tumor-bearing mice treated with PBS or clodronate liposomes to deplete macrophages (n=10). (G) The pulmonary tumor nodules of tumor-bearing mice treated with PBS or clodronate liposomes (n=10). (H) H&E staining of a representative lung of tumor-bearing mice treated with PBS or clodronate liposomes. Scale bar=200 μm. The data was presented as the mean±standard error of mean from three independent experiments. *p < 0.05.