. 2018 Oct 19;51(1):223–239. doi: 10.4143/crt.2018.073

Table 3.

Change in quality of life during first-line palliative chemotherapy in responders (CR or PR) and non-responders (SD or PD)

	Responders (CR or PR, n=116)		Non-responders (SD or PD, n=269)		p-value^b)
	No.	Mean±standard deviation	No.	Mean±standard deviation	p-value^b)
QLQ-C30
Physical functioning
Baseline	113	80.53±13.49	250	76.91±18.41
Best score	93	78.71±16.19	168	74.52±20.02
Change	92	–1.01±16.51	163	–1.84±20.49	0.985
p-value^a)		0.589		0.588
Role functioning
Baseline	113	80.68±21.54	250	75.13±25.67
Best score	93	80.65±22.69	168	70.34±28.04
Change	92	–0.72±26.83	163	–2.15±31.49	0.758
p-value^a)		0.906		0.251
Emotional functioning
Baseline	113	76.77±21.66	250	73.77±21.33
Best score	93	82.08±20.70	168	79.51±20.29
Change	92	3.80±24.19	163	8.49±21.78	0.089
p-value^a)		0.068		< 0.001
Cognitive functioning
Baseline	113	85.69±19.40	250	86.00±17.34
Best score	93	85.30±19.17	168	84.82±19.54
Change	92	–1.27±21.14	163	–0.61±21.75	0.874
p-value^a)		0.420		0.397
Social functioning
Baseline	113	67.70±32.53	250	70.40±27.77
Best score	93	76.52±21.46	168	71.33±28.07
Change	92	8.33±32.26	163	3.17±29.37	0.279
p-value^a)		0.006		0.038
Global health status/QOL
Baseline	113	50.59±23.03	250	51.50±22.90
Best score	93	60.57±20.60	168	57.14±23.22
Change	92	10.51±26.75	163	5.62±24.39	0.271
p-value^a)		< 0.001		0.003
Fatigue
Baseline	113	34.51±21.94	250	34.76±22.97
Best score	93	29.99±21.16	168	36.11±21.37
Change	92	–4.95±23.89	163	0.07±26.09	0.416
p-value^a)		0.068		0.589
Nausea and vomiting
Baseline	113	15.93±20.94	250	18.67±24.19
Best score	93	15.59±20.53	168	15.48±20.92
Change	92	–1.27±23.08	163	–4.19±25.95	0.379
p-value^a)		0.685		0.352
Pain
Baseline	113	20.65±20.45	250	25.00±25.05
Best score	93	15.41±20.15	168	18.25±24.55
Change	92	–4.53±23.06	163	–6.75±28.12	0.934
p-value^a)		0.033		0.003
Dyspnea
Baseline	113	18.88±21.30	250	15.07±22.55
Best score	93	14.70±23.29	168	16.67±23.92
Change	92	–3.62±24.93	163	1.43±27.30	0.114
p-value^a)		0.223		0.006
Insomnia
Baseline	113	23.60±29.44	250	22.93±27.35
Best score	93	16.49±23.38	168	17.66±27.52
Change	92	–7.25±33.45	163	–6.95±32.81	0.639
p-value^a)		< 0.001		0.282
Appetite loss
Baseline	113	32.15±33.01	250	35.73±34.50
Best score	93	23.30±28.14	168	30.95±31.08
Change	92	–8.70±44.44	163	–5.93±41.73	0.577
p-value^a)		0.050		0.052
Constipation
Baseline	113	23.01±30.56	250	22.93±28.78
Best score	93	15.77±22.30	168	15.87±25.26
Change	92	–7.25±31.96	163	–9.82±34.33	0.293
p-value^a)		< 0.001		< 0.001
Diarrhea
Baseline	113	17.70±27.48	250	18.13±24.82
Best score	93	12.54±21.37	168	11.31±20.58
Change	92	–7.25±29.58	163	–5.73±23.89	0.760
p-value^a)		0.507		0.002
Financial difficulties
Baseline	113	34.81±33.74	250	30.00±31.65
Best score	93	27.60±26.75	168	29.76±30.74
Change	92	–8.33±33.01	163	–1.64±32.25	0.098
p-value^a)		0.021		0.498
QLQ-STO22
Dysphagia
Baseline	113	13.08±17.52	250	16.44±19.03
Best score	93	10.39±11.68	168	13.56±16.01
Change	92	–2.90±18.48	163	–3.89±21.44	0.481
p-value^a)		0.179		0.083
Pain
Baseline	113	26.18±18.99	250	27.17±20.79
Best score	93	16.04±16.31	168	18.80±19.04
Change	92	–10.33±18.910	163	–9.51±21.47	0.669
p-value^a)		< 0.001		< 0.001
Reflux symptoms
Baseline	113	18.39±18.17	250	18.84±20.73
Best score	93	12.19±17.65	168	13.62±17.52
Change	92	–6.52±21.74	163	–6.54±19.97	0.886
p-value^a)		0.020		< 0.001
Eating restrictions
Baseline	113	21.46±18.56	250	24.83±22.15
Best score	93	14.61±15.43	168	20.49±19.79
Change	92	–7.88±20.83	163	–6.60±23.40	0.960
p-value^a)		< 0.001		< 0.001
Anxiety
Baseline	113	38.05±24.97	250	44.80±25.66
Best score	93	33.21±23.31	168	39.42±23.63
Change	92	–3.14±28.88	163	–6.34±27.33	0.203
p-value^a)		0.468		0.004
Dry mouth
Baseline	113	28.61±28.48	250	27.73±27.62
Best score	93	25.45±25.73	168	25.00±27.48
Change	92	–3.99±37.58	163	–4.70±32.47	0.838
p-value^a)		0.152		0.040
Taste
Baseline	113	21.53±28.49	250	22.80±28.19
Best score	93	20.79±24.03	168	21.43±28.56
Change	92	–1.81±32.16	163	–3.27±34.98	0.376
p-value^a)		0.676		0.138
Body image
Baseline	113	33.92±31.80	250	36.80±32.81
Best score	93	30.47±30.16	168	36.71±30.44
Change	92	–2.90±34.11	163	–1.64±35.49	0.768
p-value^a)		0.432		0.543
Hair loss
Baseline	26	48.72±35.57	54	42.59±34.52
Best score	56	30.36±33.20	103	33.98±28.77
Change	18	–18.52±44.61	29	‒2.30±34.42	0.334
p-value^a)		0.136		0.517

CR, complete response; PR, partial response; SD, stable disease; PD, progressive disease; QLQ, Quality of Life Questionnaires; QOL, quality of life.

^a)

Between best score and baseline, Wilcoxon signed rank test,

^b)

Between responders and non-responders, Kruskal-Wallis test.