Table 3.

Grade ≥ 3 adverse events in more than 2% of subjects

Adverse event	Irinotecan plus cisplatin (n=167)	Etoposide plus cisplatin (n=189)	p-valuea)
Anemia	45 (27.0)	33 (17.5)	0.035
Neutropenia	104 (62.3)	134 (71.0)	0.060
Thrombocytopenia	21 (12.6)	25 (13.2)	0.824
Neutropenic fever	31 (18.6)	33 (17.5)	0.823
Infection	34 (20.4)	33 (17.5)	0.515
Nausea	7 (4.2)	1 (0.5)	0.028
Vomiting	5 (3.0)	3 (1.6)	0.483
Diarrhea	17 (10.2)	5 (3.0)	0.003
AST elevation	2 (1.2)	8 (4.2)	0.110
ALT elevation	3 (1.8)	5 (2.6)	0.727

Values are presented as number (%).

^a)Chi-square test.