Table 4.

Effect of direct thrombin antagonists and Xa inhibitors on clotting tests, and drug-specific assays

Drug	PT		APTT		TT		Drug specific assay
	Normal	Prolonged	Normal	Prolonged	Normal	prolonged
Dabigatran	Below or within therapeutic levels	Supra-therapeutic levels	Below or within therapeutic levels	Within or above therapeutic levels	Likely little or no drug present	Cannot interpret	Dilute thrombin time or ecarin clotting time
Rivaroxaban	Therapeutic levels unlikely but cannot be excluded	Therapeutic or supratherapeutic levels	Therapeutic or subtherapeutic levels	Therapeutic or supratherapeutic levels	Unaffected		Rivaroxaban-specific anti Xa activity
Apixaban	Insensitive, cannot be assessed with these methods				Unaffected		Apixaban-specific anti Xa activity
Edoxaban	Therapeutic levels cannot be excluded		Not useful		Unaffected		Edoxaban-specific anti Xa activity

APTT = activated partial thromboplastin time; PT = prothrombin time; TT = thrombin time