Table 2.
Prevalence of p.C282Y associated baseline conditions by genotype (homozygotes, heterozygotes, and no pC282Y mutations, in participants aged 40-70 years. Values are numbers (percentages)
| Baseline conditions | Men | Women | |||||
|---|---|---|---|---|---|---|---|
| Homozygotes | Heterozygotes | No p.C282Y mutations* | Homozygotes | Heterozygotes | No p.C282Y mutations* | ||
| Haemochromatosis | 156 (12.1) | 56 (0.2) | 55 (0.03) | 54 (3.4) | 17 (0.05) | 16 (0.01) | |
| Atrial fibrillation | 27 (2.1) | 769 (2.6) | 4166 (2.4) | 13 (0.8) | 307 (0.9) | 1751 (0.8) | |
| CAD (myocardial infarction or angina) | 84 (6.5) | 2434 (8.2) | 14 341 (8.2) | 47 (2.9) | 1141 (3.3) | 6495 (3.1) | |
| Diabetes (type 1 or 2) | 61 (4.7) | 1000 (3.4) | 5523 (3.15) | 31 (1.9) | 568 (1.6) | 3371 (1.6) | |
| Liver disease | 31 (2.4) | 178 (0.6) | 910 (0.5) | 9 (0.6) | 149 (0.4) | 864 (0.4) | |
| Osteoarthritis | 182 (14.1) | 2268 (7.7) | 13 105 (7.5) | 227 (14.2) | 3780 (10.8) | 22 522 (10.8) | |
| Osteoporosis | 21 (1.6) | 206 (0.7) | 1164 (0.7) | 57 (3.57) | 1042 (2.98) | 6305 (3.03) | |
| Pneumonia | 45 (3.5) | 654 (2.2) | 3844 (2.2) | 24 (1.5) | 634 (1.8) | 3626 (1.7) | |
| Rheumatoid arthritis | 26 (2.0) | 249 (0.8) | 1552 (0.9) | 22 (1.4) | 533 (1.5) | 3399 (1.6) | |
| Tiredness | 68 (11.9) | 1085 (8.3) | 6455 (8.3) | 76 (11.4) | 1365 (9.65) | 8630 (10.1) | |
| ≥1 core haemochromatosis diagnosis† | 346 (26.7) | 3518 (11.9) | 19 778 (11.3) | 304 (19.05) | 4743 (13.6) | 28 487 (13.7) | |
| ≥1 condition (any) | 421 (32.5) | 4922 (16.7) | 28 143 (16.0) | 398 (24.9) | 6888 (19.7) | 41 531 (19.9) | |
CAD=coronary artery disease.
*
No p.C282Y mutations, irrespective of p.H63D status.
†
Includes haemochromatosis; diabetes, liver disease, including liver cancer; osteoarthritis; and rheumatoid arthritis. Any associated condition also includes osteoporosis, pneumonia, and tiredness.