Figure 3.

Representative micrographs of coronary atherosclerosis in Watanabe heritable hyperlipidemic (WHHL) and hypertensive (HTN)-WHHL rabbits. Epicardial coronary arteries exhibited prominent atherosclerosis in both groups (A), but small arteries (B) and arterioles (C) of HTN-WHHL rabbits showed various changes, including extensive stenosis (B), medial and intimal hyperplasia, hyalinization, fatty streaks, and mixed lesions that contained both hyalinization and fatty streaks (C). A normal arteriole was from a normotensive WHHL rabbit, and all other lesions were from HTN-WHHL rabbits (C). All specimens were stained with hematoxylin and eosin. Scale bars: 500 μm (A); 200 μm (B); 50 μm (C).