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. 2018 Dec;188(12):2877–2889. doi: 10.1016/j.ajpath.2018.07.030

Figure 2.

Figure 2

Progressive accumulation of microvascular cerebral amyloid angiopathy in rTg-DI rats. A–I: Brain sections from rTg-DI rats at 3 months (A–C), 6 months (D–F), and 12 months (G–I) of age were stained for fibrillar amyloid using thioflavin S (green) and immunolabeled for collagen type IV (coll IV) to identify cerebral microvessels (red). The rTg-DI rats develop early-onset and progressive cerebral microvascular fibrillar amyloid in the cortical, hippocampal, and thalamic regions. J: Quantitation of microvascular thioflavin S–positive amyloid load in different brain regions of 3-month–old (blue bars), 6-month–old (gray bars), and 12-month–old (red bars) rTg-DI rats. K: rTg-DI rats show consistently fewer return approaches within a session to four novel objects placed in an open field arena compared with wild-type rats at 3 and 12 months of age. Data are expressed as means ± SD. n = 6 to 7 rTg-DI rats per group (J and K). ∗P < 0.05. Scale bars = 50 μm (A–I).