Figure 6.

Prominent cerebral microhemorrhages in rTg-DI rats. A–F: Twelve-month–old brain sections from rTg-DI rats were stained for hemosiderin to identify microhemorrhages (blue) in the cortex (A), hippocampus (B), and the thalamus (C–F). G: The percentage area fraction of hemosiderin staining was quantitated in the cortex, hippocampus, and thalamus of 6-month–old (gray) and 12-month–old (red) rTg-DI rats. Progressive and consistent accumulation of microbleeds was observed, particularly in the thalamus, of rTg-DI rats. Data are expressed as means ± SD. n = 6 to 7 rTg-DI rats per group (G). Scale bars = 50 μm (A–F).