Figure 2.

Inhibition by tranexamic acid (TXA) of euglobulin clot lysis with single chain urokinase plasminogen activator (scuPA) or scuPA and tissue plasminogen activator (tPA) or plasmin. Clots formed from euglobulin contained plasminogen activator or plasmin and a range of TXA concentrations, and times to 50% lysis were determined. Panel A shows representative raw data for clots containing 5 nmol L⁻¹ scuPA and Panel B clots contain 5 nmol L⁻¹ scuPA + 0.6 nmol L⁻¹ tPA. Panel C shows single‐point estimates of extension of time to 50% lysis with increasing TXA concentrations at the plasmin concentrations shown. K_D estimates from these data were in the range 600–1900 μmol L⁻¹ (standard error [SE] of fitting 31–90 μmol L⁻¹).