Table 3.
Adjusted odds ratio for the association of glucocorticoid activation by 11β‐HSD with prevalent diabetes mellitus
| n | Urine (THF+5αTHF)/THE | |||||||
|---|---|---|---|---|---|---|---|---|
| Low tertile | Middle tertile | High tertile | ||||||
| OR | 95% CI | P | OR | 95% CI | P | |||
| Unadjusted | 342 | Ref. | 1.36 | 0.77‐2.42 | 0.289 | 2.57 | 1.47‐4.47 | 0.001 |
| Model A | 342 | Ref. | 1.30 | 0.70‐2.40 | 0.403 | 1.97 | 1.07‐3.62 | 0.029 |
| Model B | 331 | Ref. | 1.22 | 0.63‐2.35 | 0.556 | 2.09 | 1.09‐4.02 | 0.027 |
Binary logistic regression analysis for the association of urine (THF+5αTHF)/THE (stratified by tertiles) with prevalent diabetes. Model A: adjustment for age, sex, ethnicity, estimated glomerular filtration rate (stratified for ≤15, 15‐30, 30‐45 and >45 mL/min/1.73 m2) and C‐reactive protein (loge‐transformed). Model B: as in Model A plus adjustment for family history of diabetes and body mass index. The parameters for all covariates are reported in Table S4.
(THF+5αTHF)/THE, tetrahydrocortisol+5α‐tetrahydrocortisol/tetrahydrocortisone; 11β‐HSD, 11β‐hydroxysteroid dehydrogenase.