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. Author manuscript; available in PMC: 2019 Jan 16.
Published in final edited form as: J Proteome Res. 2015 Mar 10;14(4):1937–1946. doi: 10.1021/pr5013152

Figure 4.

Figure 4.

IL-6 regulates lipid metabolism in colon cancer. (A) qPCR analysis of IL-6 mRNA levels in the colon and liver of 5 month old WT and Apcmin/+ mice. (B) Levels of serum albumin, total protein, and blood urea nitrogen in 5 month old WT and Apcmin/+ mice. (C) Levels of serum ALT and amylase in 5 month old WT and Apcmin/+ mice. (D) qPCR analysis of the mRNAs encoding enzymes associated with fatty acid synthesis and β-oxidation in the colon of 5 month old WT and Apcmin/+ mice. (E) Hepatic mRNA levels of Cpt2, Acot1, Cyp4a10, Mcad, and Fasn in 5 month old WT and Apcmin/+ mice. (F) Cpt2, Cyp4a10, and Fasn mRNA expression of Caco-2 cells and hepatocytes after exposure to 5 ng/mL IL-6. The mRNA levels were normalized to those of β-actin mRNA. Statistical analysis was performed using two-tailed Student’s t test and ANOVA (n = 4 in each group). *, P < 0.05 and **, P < 0.01 compared to WT mice.