Figure 1.

The development of primary HCCs in rats treated with intraperitoneal administration of DEN monitored by MR imaging. (a) The changes of body weight of the rats in the two groups at different time points. (b) The representative MR images of rat livers in two groups examined by MRI with different sequences (T1WI, T2WI, and dynamic contrast-enhanced T1WI) at 15th week after DEN injection. Both T2WI and DCE-T1WI detected a nodule in the liver with 15 weeks of treatment. (c) The histopathology of the livers treated with DEN shows the representative cirrhotic change of liver lobules at the 3rd week and 8^th week after DEN administration and the typical HCC nodules in the liver at the 15th week after DEN administration.