Table 1.
Top line vaccine candidates of P. aeruginosa.
| Locus_tag | Protein annotation | Surface exposure(a) | Antigenic potential(b) | Sequence conservation(c) | Sequence conservation(d) |
|---|---|---|---|---|---|
| PA0328 | arginine-specific autotransporter AaaA | Yes | Yes | 99.3% ± 0.2% | 99.2% ± 0.3% |
| PA1178 | outer membrane protein OprH precursor | Yes | Yes | 100% ± 0% | 99.9% ± 0.2% |
| PA1248 | outer membrane protein AprF precursor | Yes | Yes | 99.6%± 0.3% | 99.2%± 4.6% |
| PA2407 | putative adhesion protein FpvC | Yes | Yes | 100% ± 0% | 98.3% ± 10.4% |
| PA3526 | outer membrane protein precursor MotY | Yes | Yes | 99.1% ± 0.8% | 99.7% ± 0.5% |
| PA4082 | adhesive protein CupB5 | Yes | Yes | 98.8% ± 0.5% | 98.5% ± 2.9% |
| PA4765 | outer membrane lipoprotein OmlA precursor | Yes | Yes | 99.7% ± 0.3% | 98.9% ± 7.2% |
| PA5047 | putative Zn-dependent protease | Yes | Yes | 99.9% ± 0.1% | 99.2% ± 7.1% |
| PA5112 | esterase EstA | No | Yes | 99.8% ± 0.2% | 99.1% ± 7.2% |
| PA5340 | hypothetical protein | Yes | Yes | 98.8% ± 0.3% | 99.2% ± 0.3% |
a
Surface exposure suggested by immunofluorescence microscopy co-localization (see text).
b
Evaluated by Western Blot against recombinant proteins, P. aeruginosa strain PAO1 and clinical isolate MDR-RP73 (see text). Sequence conservation expressed as mean percentage of amino acid identity ± standard deviation calculated among a collection of CF clinical strains
c
and on the public collection of 104 completed P. aeruginosa genomes available in GenBank (see text)d.