Table 3.
Comorbidities in patients with multifocal and oligofocal osteonecrosis (ON)
| Comorbidity | Multifocal ON (n = 18/26) |
Oligofocal ON (n = 70/228) |
Any ON (N = 88/254) |
|---|---|---|---|
| Immune system disease | 8 | 26 | 34 |
| Ulcerative colitis | 1 | 1 | |
| Rheumatoid arthritis | 5 | 5 | |
| AOSD | 1 | 1 | |
| Systemic lupus erythematosus | 3 | 7 | 10 |
| MCD, MGN, IgA nephropathy | 2 | 7 | 9 |
| ANCA-associated vasculitis | 1 | 1 | 2 |
| Dermatomyositis | 3 | 3 | |
| Sarcoidosis, Behçet’s disease, vitalism | 1 | 2 | 3 |
| ESRD with KT | 3 | 6 | 9 |
| Malignancy | 2 | 16 | 18 |
| Lung cancer | 1 | 1 | |
| Stomach cancer | 1 | 2 | 3 |
| Renal cancer | 2 | 2 | |
| Breast cancer | 1 | 5 | 6 |
| Neuroblastoma | 2 | 2 | |
| Rectal cancer | 2 | 2 | |
| Gall bladder cancer | 1 | 1 | |
| Hepatocellular carcinoma | 1 | 1 | |
| Hematological diseases | 4 | 4 | |
| Acute myelocytic leukemia | 1 | 1 | |
| Multiple myeloma | 1 | 1 | |
| Aplastic anemia | 2 | 2 | |
| Mitral valve stenosis, with operation | 1 | 1 | |
| Spinal cord tumor, meningioma, pheochromocytoma | 1 | 2 | 3 |
| Craniopharyngioma, seizure | 1 | 1 | 2 |
| Osteoporosis with bisphosphonate treatment | 2 | 2 | |
| Bronchiectasis | 1 | 1 | |
| Facial palsy, hearing loss, trigeminal neuralgia | 1 | 2 | 3 |
| Recurrent oral ulcer, recurrent uveitis | 1 | 1 | 2 |
| Allergic disease (urticarial, Steven-Johnson), vitalism, asthma | 1 | 5 | 6 |
| Liver cirrhosis, intraperitoneal bleeding | 3 | 3 |
ON osteonecrosis, AOSD adult onset Still’s disease, MCD minimal change disease, MGN membranous glomerulonephritis, ANCA anti-neutrophil cytoplasmic antibody, ESRD end-stage renal disease, KT kidney transplantation