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. 2019 Jan 15;38:19. doi: 10.1186/s13046-018-1010-1

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 9 — Combination of GEN and STAT3 shRNA inhibited xenograft growth by co-injection of SKOV3-derived OCSLCs and THP-1 macrophages. The nude mouse xenograft model using co-injection with OCSLCs/THP-1 macrophages was treated with GEN (50 mg/kg) and Ad-shSTAT3 alone or in combination. The size (a) volume (b), weight (c), histological examination (HE staining) and the expression of CD68, IL-8 and p-STAT3 (immunohistochemical staining) (d) of xenografts were shown (scale bar, 100 μm). *P < 0.05, vs the model control group; ^#P < 0.05, vs treated with GEN (50 mg/kg) or Ad-shSTAT3 alone (means±SD, n = 4)