Table 2.
Analysis of the association between the MTHF methylation profile and A1298C polymorphism of MTHFR and the biochemical, inflammatory and oxidative stress variables
| Methylated (42) | Partially methylated (65) | ||||||
|---|---|---|---|---|---|---|---|
| AA (22) | AC (17) + CC (3) | p | AA (36) | AC (23) + CC (6) | p | ||
| HbA1c | Mean ± SD Median |
8.6 ± 1.7 8.4 |
7.9 ± 2.3 7.2 |
0.0718 | 7.9 ± 1.8 7.6 |
8.7 ± 1.8 9.0 |
0.0516 |
| Min.–Max. | 5.7–13.0 | 5.3–14.4 | 4.1–12.7 | 4.3–11.2 | |||
| GLIC | Mean ± SD Median |
186.1 ± 52.5 163.5 |
157.4 ± 51.5 135.0 |
0.0366* | 159.8 ± 60.7 151.0 |
166.4 ± 70.0 145.0 |
0.8794 |
| Min.–Max. | 121.0–301.0 | 85.0–282.0 | 72.0–308.0 | 85.0 ± 359.0 | |||
| TC | Mean ± SD Median |
222.1 ± 47.6 214.3 |
164.6 ± 28.3 163.0 |
0.0001* | 195.5 ± 56.5 187.0 |
195.7 ± 47.1 192.0 |
0.8225 |
| Min.–Max. | 133.0–345.0 | 93.0–224.0 | 96.0 ± 320.0 | 127.0–316.0 | |||
| HDL | Mean ± SD Median |
43.6 ± 9.4 42.0 |
46.1 ± 9.5 45.0 |
0.3918 | 46.1 ± 10.8 45.0 |
39.8 ± 11.6 39.0 |
0.0179* |
| Min.–Max. | 27.0–62.0 | 30.0–61.0 | 30.0–75.0 | 21.0–75.0 | |||
| LDL | Mean ± SD Median |
134.8 ± 48.0 131.7 |
86.1 ± 30.7 84.7 |
0.0006* | 119.0 ± 51.2 114.5 |
112.6 ± 50.6 110.4 |
0.7565 |
| Min.–Max. | 29.0–227.0 | 29.4–158.4 | 46.8 ± 218.8 | 30.0–251.6 | |||
| TRIG | Mean ± SD Median |
216.0 ± 129.1 196.5 |
184.0 ± 86.4 165.5 |
0.4350 | 177.8 ± 91.4 158.0 |
211.2 ± 106.8 177.0 |
0.1937 |
| Min.–Max. | 56.0–650.0 | 55.0–398.0 | 67.0–488.0 | 53.0–484.0 | |||
| CREA-S | Mean ± SD Median |
0.8 ± 0.3 0.8 |
0.8 ± 0.3 0.8 |
0.7529 | 0.9 ± 0.4 0.8 |
0.9 ± 0.3 0.8 |
0.4362 |
| Min.–Max. | 0.4–1.4 | 0.4–1.7 | 0.5–2.2 | 0.5–2.2 | |||
| M. ALB | Mean ± SD Median |
61.7 ± 140.5 18.0 |
20.4 ± 22.9 9.3 |
0.4651 | 79.8 ± 161.6 21.3 |
48.9 ± 129.9 7.2 |
0.0705 |
| Min.–Max. | 1.0–650.0 | 1.0–76.0 | 1.0–650.0 | 1.0–525.0 | |||
| RCP | Mean ± SD Median |
4.2 ± 3.7 3.8 |
3.3 ± 2.5 2.5 |
0.5839 | 3.6 ± 3.6 1.8 |
3.1 ± 2.9 2.2 |
0.7766 |
| Min.–Max. | 0.4–13.3 | 0.4–9.5 | 0.3 ± 11.7 | 0.1–11.7 | |||
| AGP | Mean ± SD Median |
95.0 ± 40.8 86.0 |
84.0–21.8 83.0 |
0.4652 | 74.5 ± 29.2 71.0 |
80.0 ± 25.8 76.0 |
0.3454 |
| Min.–Max. | 59.0–263.0 | 55.0–140.0 | 4.0–176.0 | 21.0–172.0 | |||
| TAC | Mean ± SD Median |
40.8 ± 28.0 42.0 |
55.0 ± 27.0 61.0 |
0.1337 | 24.8 ± 25.6 12.0 |
26.9 ± 25.0 13.0 |
0.4800 |
| Min.–Max. | 5.0–91.0 | 8.0–94.0 | 2.0–96.0 | 4.0–84.0 | |||
| MDA | Mean ± SD Median |
3.4 ± 1.1 3.7 |
3.9 ± 0.6 3.7 |
0.3579 | 3.5 ± 1.3 3.7 |
3.3 ± 1.4 3.4 |
0.4843 |
| Min.–Max. | 1.1–4.9 | 3.1–5.1 | 1.0–6.2 | 1.4–6.3 | |||
HbA1C (%) glycated haemoglobin, GLIC (mg/dL) fasting glycemia, TC (mg/dL) total cholesterol, HDL (mg/dL) high density lipoprotein, LDL (mg/dL) light density lipoprotein cholesterol, TRIG (mg/dL) triglycerides, CREA-S (mg/dL) serum creatinine, M. ALB (mg/dL) 24 h albumin excreted in the urine, RCP (mg/dL) reactive C protein, AGP (mg/dL) alfa 1 acid glycoprotein, TAC (%) total antioxidant capacity, MDA (µM) malondialdehyde
* Statistically significant (p < 0.05), Mann–Whitney test