Table 1.
Correlation between FGF9 expression and clinicopathological parameters of gastric adenocarcinomas
| Features | N | PTCAF-FGF9 expression(%) | p value | PT-FGF9 expression(%) | p value | N | LNCAF-FGF9 expression(%) | p value | LNT-FGF9 expression(%) | p value | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| low | high | low | high | low | high | low | high | |||||||
| Total | 160 | 112(70.0) | 48(30.0) | 141(88.1) | 19(11.9) | 106 | 72(67.9) | 34(32.1) | 93(87.7) | 13(12.3) | ||||
| Age | ||||||||||||||
| < 60 | 54 | 42(77.8) | 12(22.2) | 0.125 | 53(98.1) | 1(1.9) | 0.005* | 38 | 30(79.0) | 8(21.0) | 0.069 | 36(94.7) | 2(5.3) | 0.129 |
| ≥60 | 106 | 70(66.0) | 36(34.0) | 88(83.0) | 18(17.0) | 68 | 42(61.8) | 26(38.2) | 57(83.8) | 11(16.2) | ||||
| sex | ||||||||||||||
| male | 115 | 83(72.2) | 32(27.8) | 0.337 | 100(87.0) | 15(13.0) | 0.465 | 75 | 50(66.7) | 25(33.3) | 0.666 | 63(84.0) | 12(16.0) | 0.102 |
| female | 45 | 29(64.4) | 16(39.6) | 41(91.1) | 4(8.9) | 31 | 22(71.0) | 9(29.0) | 30(96.8) | 1(3.2) | ||||
| tumor size | ||||||||||||||
| < 5 | 57 | 45(79.0) | 12(21.0) | 0.066 | 53(93.0) | 4(7.0) | 0.158 | 38 | 27(71.1) | 11(28.9) | 0.606 | 32(84.2) | 6(15.8) | 0.408 |
| ≥ 5 | 103 | 67(65.0) | 36(35.0) | 88(85.4) | 15(14.6) | 68 | 45(66.2) | 23(33.8) | 61(89.7) | 7(10.3) | ||||
| Location | ||||||||||||||
| GEJ-Cardia | 24 | 15(62.5) | 9(37.5) | 0.029* | 22(91.7) | 2(8.3) | 0.392 | 18 | 9(50.0) | 9(50.0) | 0.113 | 16(88.9) | 2(11.1) | 1.000 |
| Fundus-Body | 41 | 30(73.2) | 11(26.8) | 38(92.7) | 3(7.3) | 28 | 22(78.6) | 6(21.4) | 25(89.3) | 3(10.7) | ||||
| Antrum-Pylorus | 87 | 65(74.7) | 22(25.3) | 75(86.2) | 12(13.8) | 57 | 40(70.2) | 17(29.8) | 49(86.0) | 8(14.0) | ||||
| Remnant+ multi-sites | 8 | 2(25.0) | 6(75.0) | 6(75.0) | 2(25.0) | 3 | 1(33.3) | 2(66.7) | 3(100) | 0(0) | ||||
| Differentiation | ||||||||||||||
| well-moderate | 25 | 16(64.0) | 9(36.0) | 0.476 | 21(84.0) | 4(16.0) | 0.503 | 16 | 7(43.8) | 9(56.2) | 0.025* | 13(81.3) | 3(18.7) | 0.411 |
| poor | 135 | 96(71.1) | 39(28.9) | 120(88.9) | 15(11.1) | 90 | 65(72.2) | 25(27.8) | 80(88.9) | 10(11.1) | ||||
| Lauren type | ||||||||||||||
| intestinal | 68 | 49(72.1) | 19 (27.9) | 0.625 | 57(83.8) | 11(16.2) | 0.148 | 46 | 25(54.4) | 21(45.6) | 0.009* | 37(80.4) | 9(19.6) | 0.045* |
| diffuse+mixed | 92 | 63(68.5) | 29(31.5) | 84(91.3) | 8(8.7) | 60 | 47(78.3) | 13(21.7) | 56(93.3) | 4(6.7) | ||||
| pT stage | ||||||||||||||
| T1 + T2 | 17 | 14(82.4) | 3(17.6) | 0.240 | 17(100) | 0(0) | 0.226 | 12 | 9(75.0) | 3(25.0) | 0.577 | 11(91.7) | 1(8.3) | 1.000 |
| T3 + T4 | 143 | 98(68.5) | 45(31.5) | 124(86.7) | 19(13.3) | 94 | 63(67.0) | 31(33.0) | 82(87.2) | 12(12.8) | ||||
| pN stage | ||||||||||||||
| N0 | 31 | 18(58.1) | 13(41.9) | 0.407 | 28(90.3) | 3(9.7) | 0.792 | / | / | / | / | / | / | |
| N1 | 35 | 26(74.3) | 9(25.7) | 29(82.9) | 6(17.1) | 20 | 16(80.0) | 4(20.0) | 0.175 | 17(85.0) | 3(15.0) | 0.599 | ||
| N2 | 29 | 22(75.9) | 7(24.1) | 26(89.7) | 3(10.3) | 24 | 13(54.2) | 11(45.8) | 20(83.3) | 4(16.7) | ||||
| N3 | 65 | 46(70.8) | 19(29.2) | 58(89.2) | 7(10.8) | 62 | 43(69.4) | 19(30.6) | 56(90.3) | 6(9.7) | ||||
| M stage | ||||||||||||||
| M0 | 157 | 110(70.1) | 47(29.9) | 1.000 | 139(88.5) | 18(11.5) | 0.317 | 103 | 70(68.0) | 33(32.0) | 1.000 | 90(87.4) | 13(12.6) | 1.000 |
| M1 | 3 | 2(66.7) | 1(33.3) | 2(66.7) | 1(33.3) | 3 | 2(66.7) | 1(33.3) | 3(100) | 0(0) | ||||
| TNM stage | ||||||||||||||
| I + II | 63 | 42(66.7) | 21(33.3) | 0.458 | 55(87.3) | 8(12.7) | 0.795 | 20 | 14(70.0) | 6(30.0) | 0.825 | 16(80.0) | 4(20.0) | 0.262 |
| III + IV | 97 | 70(72.2) | 27(27.8) | 86(88.1) | 11(11.9) | 86 | 58(67.4) | 28(32.6) | 77(89.5) | 9(10.5) | ||||
*p < 0.05